Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 12;13:655. doi: 10.1038/s41598-022-27169-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Representative images of LA-ICP-MSI in MS pons and control samples I. The position of the locus ceruleus is within the dashed circles. (a) MS05. Posterior pons: locus ceruleus ^MSIPTEs are silver, aluminium, and iron. Iron is also present in non-locus ceruleus regions (green), and around small blood vessels (arrows). Lead is seen in the leptomeninges and subpial regions (arrowhead). Anterior pons: iron in present in linear white matter tracts, and both in (red) and around (green) blood vessels (arrow). Linear silver is present. (b) MS14. Posterior pons: locus ceruleus ^MSIPTEs are iron, nickel (focal), and lead. Iron (green) is also present in non-locus ceruleus regions. Silver and nickel are seen in subpial regions (arrowheads), with possible penetration of silver into deeper tissue (*). Anterior pons: iron and mercury are present in linear regions, with iron in and around blood vessels (arrow). (c) CN12. Posterior pons: locus ceruleus ^MSIPTEs are silver and iron. Iron (green) is also present in extra-locus ceruleus regions, and around blood vessels (arrow). Lead and nickel are seen in subpial (arrowheads) and subependymal (thin arrow) regions. Anterior pons: Iron is present in linear regions and in and around blood vessels (arrow). Linear iron and silver are present. (d) CN05. Posterior pons: locus ceruleus ^MSIPTEs detected are silver, iron, and mercury. Iron (green) is also present in extra-locus ceruleus regions. Lead and nickel are seen in subpial regions (arrowheads) and nickel in subependymal regions (thin arrow). Anterior pons: Iron in present in linear white matter tracts and in and around blood vessels (arrow). Linear deposits of silver are seen.