Skip to main content
. Author manuscript; available in PMC: 2024 Jan 13.
Published in final edited form as: Alzheimers Dement. 2022 Jul 13;19(3):980–998. doi: 10.1002/alz.12714

Figure 1: Study overview.

Figure 1:

500 ROS/MAP participants were included in this analysis. For each participant, data was available on cognitive assessments during lifetime, postmortem AD brain pathology, and brain metabolic profiles from the dorsolateral prefrontal cortex (DLPFC) region. Metabolic profiles were investigated for associations with AD-related traits and a metabolite interaction network was inferred using a Gaussian graphical model (GGM). Associations were tested for replication in 83 temporal cortex samples from the Mayo Clinic brain bank cohort and compared to a previously published brain-based study. Finally, various pathways previously implicated in AD were metabolically characterized, and a detailed metabolomic/proteomic characterization of the glutamate/GABA neurotransmitter pathway was generated.