a, Metabolites measured in brain samples are distributed
across various metabolic classes, referred to as “super-pathways”
throughout the manuscript. b, Kendall correlations across the eight
AD-related traits. c, A total of 298 metabolites were associated
with at least one of the eight AD-related traits. d, Examples of
two metabolites with the lowest adjusted p-values. Note that the traits were
discretized (median split) for visualization. e, Distribution of
metabolic associations across super-pathways. f, Gaussian graphical
model of metabolites. Metabolites are colored based on the negative
log10 of the lowest adjusted p-value across AD-related traits
multiplied with the direction of the respective effect estimate. Global NP =
Global burden of AD neuropathology. NP Diagnosis = postmortem diagnosis based on
Braak stage and CERAD score. Cognition = cognitive assessment scores from last
premortem test. Cognitive Decline = Change in cognitive assessment scores over
time until death.