Fig. 1.

APLIOS study design with sNfL sampling time points. ^aNine months or until the B cells returned to their baseline value or to LLN; ^brandomization was stratified by body weight (< 60 kg, 60–90 kg, and > 90 kg); ^cday 7 to day -1; ^din case of relapse, if an MRI for efficacy was to be scheduled within 14 days of the initiation of steroid treatment, the MRI was performed before steroid treatment was initiated. No MRI for efficacy was performed while a patient was on steroid therapy for relapse and within 14 days upon termination of steroid therap. ^eOn non-injection visits the PK (Plasma) and neurofilament samples were drawn at any time during the visit. AI autoinjector; BL baseline; HCP healthcare professional; LLN lower limit normal; MRI magnetic resonance imaging; PFS prefilled syringe; PK pharmacokinetics; sNfL serum neurofilament light chain