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. 2022 Dec 19;12(1):303–317. doi: 10.1007/s40120-022-00427-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Temporal association of sNfL levels and Gd + T1 lesions in patients free of Gd + T1 lesions at baseline: A patients (N = 13) Who only had Gd + T1 lesions on the week 4 scan and B patients (N = 7) who had Gd + T1 lesions on both week 4 and week 8 scans. Additive mixed model with a nonparametric smoother of time adjusted for age and log of baseline sNfL. ^aPatients were free of Gd + T1 lesions at baseline. Gd + gadolinium enhancing; sNfL serum neurofilament light chain