Table 2.
Selected model input parameters for the analysis of second-line CAR-T in late relapse patients
| Inputs: outcome probabilities | Base case | Sensitivity analysis range | Monte Carlo distribution | References |
|---|---|---|---|---|
| Proportion of RR-DLBCL patients with primary refractory/early relapsed disease | 0.65 | 0.50-0.80 | β | 1,32,33 |
| Salvage chemoimmunotherapy as a bridge to auto-SCT in second-line setting in late relapse patients | ||||
| Clinical outcomes | ||||
| EFS rate at 3 y | 0.45 | 0.35-0.70 | β | 1 |
| OS rate at 3 y | 0.52 | 0.32-0.75 | β | 1 |
| Overall response rate | 0.88 | 0.70-0.95 | β | 1 |