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. 2022 Aug 5;140(18):1951–1963. doi: 10.1182/blood.2022015646

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© 2022 by The American Society of Hematology.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Figure 1. — A CRISPR library screen identifies ATLL cell-intrinsic molecules for immune escape from YT1–NK cell line-mediated cytotoxicity. (A) Schematic design of CRISPR library screening in this study. Two Cas9-expressing ATLL cell lines, ST1 and KK1, were analyzed. (B) Selection criteria for ATLL cell-intrinsic genes whose knockout lead to escape from NK cytotoxicity. (C) Log₂ fold changes (treated/not treated) of single guide RNAs (sgRNAs) targeting selected resistance genes. (D) Log₂ fold changes (treated/not treated) of known NK-cell receptor ligands in our screening. (E) Selection criteria for ATLL-cell–intrinsic genes whose knockout lead to sensitization of NK cytotoxicity. (F) Log₂ fold changes (treated/not treated) of sgRNAs targeting selected sensitizing genes.