Table 2.
Naturally occurring amino acid substitutions in tarS, tarM and tarP with function of the original residue
|
tar gene |
Substitution |
Isolates (n) |
Function of the residue |
|---|---|---|---|
|
tarS |
D91H |
14 |
Interaction with C3-OH of GlcNAc [6] |
|
E177K |
6 |
Interaction with C4-OH and C6-OH of GlcNAc [6] |
|
|
S212R |
3 |
Coordinates β-phosphate of UDP-GlcNAc [6] |
|
|
tarM |
G17D |
2 |
Interaction with α-phosphate of the UDP-GlcNAc [8] |
|
tarP |
T10P |
7 |
F11 is important for GlcNAc interaction [7] |