Fig. 3.

DTI scalars calculated longitudinally in HD (n = 4; purple, top panel) and control females (n = 3; bottom panel) at 9 years of age and again at 10 years of age. A) DTI scalars were calculated in regions of interest (ROIs) located in rostral and caudal internal capsule, motor, parietal and occipital cortex. B) Directionality of water diffusion along the axon in white matter (FA) decreased in females from 9 to 10 years of age (top; in red, green, purple, and blue) compared to normal controls (bottom; in orange, maroon and black). B) Similarly, water diffusion increased in all directions of white matter (ADC; C) and throughout the white matter boundaries (RD; D) over one year. DTI scalars for control sheep remained  1±0.1.