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. 2022 Dec 16;11(4):391–406. doi: 10.3233/JHD-220526

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© 2022 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — Correlation of DTI scalars with mHTT levels in CSF and neurological scores. A) mHTT levels in CSF of HD females (n = 5) sampled at 9 and 10 years of age nearly correlates with directionality of water diffusion (FA), overall diffusivity (ADC), and diffusion through the white matter boundaries (RD) of occipital cortex. Occipital cortex-FA showed significant correlation with clinical rating score in B) males (n = 7) and females (n = 25) combined and C) 10-year-old females. D–F) DTI scalars (ADC, RD, AD) calculated in corpus callosum of 10-year-old females (n = 17) showed significant correlation with gait scores. M and F in the legends represent male and female sheep respectively.