Table 2.

Multiple linear regression

A) Dependent variable: Cmax (R2 = 0.51)
Coefficients	Estimate	Std. Error	t value	p
(intercept)	0.98	0.42	2.34	0.020
Age (y)	0.003	0.004	0.76	0.450
Weight (kg)	–0.01	0.003	–3.65	<0.001
Sex
Male	(base)
Female	0.54	0.08	6.50	<0.001
MDS-UPDRS part III “off”	0.01	0.003	2.91	0.004
Test dose (mg)
50	(base)
100	0.87	0.24	3.66	<0.001
150	1.39	0.28	5.03	<0.001
200	3.20	0.27	11.69	<0.001
Dopa decarboxylase inhibitor
Carbidopa	(base)
Benserazide	0.28	0.09	3.28	0.001
B) Dependent variable: AUC (R2 = 0.73)
Coefficients	Estimate	Std. Error	t value	p
(intercept)	72.36	20.59	3.51	<0.001
Age (y)	0.48	0.18	2.68	0.008
Weight (kg)	–1.08	0.14	–7.65	<0.001
Sex
Male	(base)
Female	34.00	4.05	8.39	<0.001
MDS-UPDRS part III “off”	0.49	0.13	3.80	<0.001
Test dose (mg)
50	(base)
100	77.22	11.76	6.56	<0.001
150	145.85	13.60	10.72	<0.001
200	261.88	13.46	19.46	<0.001
Dopa decarboxylase inhibitor
Carbidopa	(base)
Benserazide	10.13	4.19	2.42	0.016

C_max, peak plasma concentration; MDS-UPDRS, Movement Disorder Society Unified Parkinson’s Disease Rating Scale; AUC, area under the plasma concentration-time curve.