Fig. 5.

The SynFib model is also applicable in mice. In the experiment illustrated here PFFs were injected together with AAV-α-syn (“Mixed”) or 4 weeks after the AAV injection (“Delayed”). The injections were made at a single site in the SN, unilaterally, and the mice were analyzed 12 weeks later. The extent of TH+cell loss and behavioral impairment induced by the mixed AAV/PFF injection was similar to those seen in rats (see Fig. 2), and they tended overall to be more pronounced than in the delayed group. In the rotation test one mouse of each group did not move and were for this reason not included. In one mouse of the Mixed group cell counting could not be performed due to damage caused during sectioning. Scale bars in A and B: 1 mm. Unpublished data.