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. 2022 Dec 16;12(8):2321–2338. doi: 10.3233/JPD-223363

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© 2022 – The authors. Published by IOS Press

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Similar impact of insulin/IGF-1 and mTOR pathway manipulations on aging and PD-related neurodegeneration. Impact of dietary and genetic manipulations on several key nodes throughout the insulin/IGF-1 and connected mTOR signaling pathway on aging and PD-related neurodegeneration are shown. Green boxes denote beneficial effects (i.e., delayed/attenuated aging or PD neurodegeneration) and orange boxes denote deleterious effects (i.e., accelerated aging or PD neurodegeneration). Figure was created on BioRender.com.