Table 1.
Brain Microcirculation: Pressing questions
| How does brain capillary RBC flux and distribution change from rest-↑metabolic rates in health and disease? |
| Is the necessary homogenization of capillary hematocrit across units impacted in disease? |
| How does this affect blood-tissue O2/substrate delivery? |
| What is the distribution of PO2 s across the capillary, interstitium and intracellular space at rest and during ↑ metabolic rates in health and disease? |
| What might be the role of pericytes in re-distributing RBC distribution? |
| How can regular exercise improve brain capillary function to improve O2 delivery? |
| What is the best exercise format –resistance, endurance and what frequency, duration and intensity? |
Key questions pertaining to brain microcirculation that the model of capillary function shown in Figure 3 could address.