Scheme 6.
Preparation and derivatization of the bromo regioisomers 27 and 28.
Reagents and conditions. a. diethyl oxalate, reflux; b. SOCl2, DMF cat.; c. Malononitrile, NaH, DME; d. 92, NMP; e. H2SO4; f. BBr3, CH2Cl2; g. RB(OR)2, Pd(dppf)Cl2.CH2Cl2, K2CO3, DMF or CuCN, DMF.