Skip to main content
. Author manuscript; available in PMC: 2023 Aug 11.
Published in final edited form as: J Med Chem. 2022 Jul 26;65(15):10251–10284. doi: 10.1021/acs.jmedchem.2c00552

Table 4.

Potency of substituted phenyl ring analogs.

graphic file with name nihms-1859502-t0028.jpg
R1 R2 R3 R4 PKMYT1 Enzymatic IC50 (μM) PKMYT1 cell assayIC50 (μM)
26 H H H Br <0.003 0.19
27 H H Br H 0.005 1.37
28 H Br H H <0.003 0.36
29 Br H H H <0.003 0.021
30 H H H CN 0.004 0.036
31 H H H graphic file with name nihms-1859502-t0029.jpg <0.003 0.12
32 H H H graphic file with name nihms-1859502-t0030.jpg <0.003 0.55
33 H CN H H 0.005 0.20
34 H graphic file with name nihms-1859502-t0031.jpg H H 0.004 0.17
35 H graphic file with name nihms-1859502-t0032.jpg H H 0.005 0.30
36 CN H H H 0.005 0.034
37 graphic file with name nihms-1859502-t0033.jpg H H H 0.006 0.32
38 graphic file with name nihms-1859502-t0034.jpg H H H 0.008 1.05