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. Author manuscript; available in PMC: 2023 Jan 13.
Published in final edited form as: J Endocrinol. 2022 Aug 9;254(3):121–135. doi: 10.1530/JOE-21-0447

Figure 1.

Figure 1

Metabolic phenotyping of MKR and WT mice before and at onset of puberty. (A) Mean body weight ± s.e.m. (g), n = 6–10 mice in each group at each time point. (B) Insulin tolerance test: blood glucose levels following administration of insulin (1 μ/kg body weight), n = 3 mice in each group at each end point. Shaded area represents hypoglycemia, at glucose levels <60 mg/dL. MKR vs WT at pre-puberty: +P < 0.05; WT vs MKR at VO: *P < 0.05, **P < 0.005, ***P < 0.005. (C) IGF-1 levels (pg/mL), n = 8–12 each group at each end point. (D) Insulin levels (ng/mL), n = 11–14 in each group at each end point. ▲MKR, O WT. *P < 0.05; **P < 0.005; ***P < 0.0005; ****P < 0.0001.