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. Author manuscript; available in PMC: 2023 Jan 13.
Published in final edited form as: Cell Rep. 2022 Nov 29;41(9):111717. doi: 10.1016/j.celrep.2022.111717

Figure 6. Network-based discovery of repurposable drug candidates for AD.

Figure 6.

Drug-AD associations were evaluated by the network proximity between predicted alzRGs and drug-target networks.

(A) 118 prioritized drugs for AD treatment (Table S5). Drugs are grouped by fourteen different classes (e.g., immunological, respiratory, neurological, cardiovascular, and cancer) defined by the first level of the Anatomical Therapeutic Chemical (ATC) codes.

(B) Proposed mechanism of actions (MOAs) for gemfibrozil by drug-target network analysis.

(C) Proposed MOAs for cholecalciferol by drug-target network analysis.