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. 2023 Jan 13;21:25. doi: 10.1186/s12967-023-03879-0

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Dynamic change of soluble PD-L1 level after chemotherapy or targeted therapy. a No significant change was observed after systemic therapies. b sPD-L1 level showed no difference grouped by different response to chemotherapy or targeted therapy. Dynamic change of sPD-L1 level from cycle 1 (C1) to cycle 4 (C4) showed no significant change in different response subgroups c and targeted drug subgroups d