Fig. 6.

In vivo therapeutic effects of free Cel, NM@F127-Cel and R4F-NM@F127-Cel in CIA mice. a Experimental schedule of CIA induction and R4F-NM@F127-Cel injection. Inj, injection. b–e CIA clinical symptoms were effectively attenuated by intravenous administration of different treatments. The body weight (b), clinical scores (c), and ankle diameter (mm) of the left hind paw (d) and the right hind paw (e) of mice were evaluated every 3 days until sacrifice. f Representative gross lesions, micro-CT examination, H&E staining, and S&O staining. (100×). Data are presented as the mean ± SEM (n = 4) and were statistically analyzed using one-way ANOVA followed by Tukey’s multiple comparisons test by comparing the group marked with * with the model group. ns represents no significant difference. *p < 0.05, ***p < 0.001; ^#p < 0.05, and ^###p < 0.001