Table 4.
Top five GO-BP terms filtered by fold enrichment > 5 (compa2) in order highest to lowest
| Term | Term name | Count | P-value | Genes* | Fold enrichment | P-adjusted# |
|---|---|---|---|---|---|---|
| GO:0048678 | Response to axon injury | 9 | 2.66E-08 | P11232 (Txn), P20294 (Cntf), P23593 (Apod), P02650 (Apoe), P15800 (Lamb2), P11762 (Lgals1), P16884 (Nefh), P19527 (Nefl), P12839 (Nefm), R4GNK3 (Txn1) | 18.49 | 7.03E-05 |
| GO:0006979 | Response to oxidative stress | 15 | 1.21E-07 | P63039 (Hspd1), P63018 (Hspa8), P02650 (Apoe), P16884 (Nefh), P31044 (Pebp1), Q8K3R4 (Adipoq), R4GNK3 (Txn1), P11232 (Txn), Q9R063 Prdx5, Q9WVH8 (Fbln5), P23593 (Apod), P07943 (Akr1b1), P12839 (Nefm), P23928 (Cryab), O35244 (Prdx6), P62909 (Rps3) | 6.11 | 7.97E-05 |
| GO:0061564 | Axon development | 15 | 1.03E-07 | P20294 (Cntf), P02688 (Mbp), P02650 (Apoe), Q4QRB4 (Tubb3), P60203 (Plp1), P15800 (Lamb2), P19527 (Nefl), P16884 (Nefh), F1M614 (Lama2), P50398 (Gdi1), Q00981 (Uchl1), P13668 (Stmn1), P23593 (Apod), P12839 (Nefm), P47942 (Dpysl2) | 6.19 | 9.11E-05 |
| GO:0031103 | Axon regeneration | 7 | 2.69E-07 | P20294 (Cntf), P23593 (Apod), P02650 (Apoe), P15800 (Lamb2), P16884 (Nefh), P19527 (Nefl), P12839 (Nefm) | 25.78 | 1.02E-04 |
| GO:0007017 | Microtubule-based process | 17 | 9.24E-08 | Q5PPN5 (Tppp3), P63018 (Hspa8), Q4QRB4 (Tubb3), P41350 (Cav1), P19527 (Nefl), P16884 (Nefh), A0A0G2JYB1 (Capzb), Q6P9T8 (Tubb4b), P68370 (Tuba1a), Q5XIF6 (Tuba4a), Q00981 (Uchl1), A0A0H2UHM7 (LOC100909441), P13668 (Stmn1), P69897 (Tubb5), P12839 (Nefm), P23928 (Cryab), P62909 (Rps3) | 5.28 | 1.22E-04 |
*UniProt accession references and names (SWISSPROT and TrEMBL). #Benjamini-Hochberg correction. Three terms out of five are related to axon development/injury, one comprises proteins involved in response to oxidative stress, and one contains proteins involved in microtubule processes. Compa2: Comparison between SNC and the WT rats 1 month after injury. CMT1A: Charcot-Marie-Tooth-1A; GO-BP: Gene Ontology Biological Process; WT: wild-type.