Additional Table 1.
Gene Ontology-Biological Process terms of CMT1A versus WT (compa1) filtered by statistical significance and fold enrichment > 5
| Term | Count | P-value | Genes | Fold enrichment | P adjusted (Benjamini-Hochberg correction) |
|---|---|---|---|---|---|
| Response to reactive oxygen species | 14 | 1.51E-07 | P10960, P07632, P04906, P63018, P35704, Q63716, R4GNK3, A0A0G2JSV6, Q9R063, P07150, P23593, P30904, P07943, P05197 | 6.749 | 2.54E-04 |
| Cellular response to reactive oxygen species | 10 | 5.68E-06 | Q9R063, P10960, P07150, P07632, P63018, P35704, P30904, Q63716, P07943, R4GNK3 | 7.743 | 0.0010 |
| Protein folding | 10 | 8.33E-06 | P10111, P63018, P34058, P14659, P82995, P26772, P11598, Q66HD0, P35565, R4GNK3 | 7.385 | 0.0014 |
| Cellular response to oxidative stress | 12 | 1.20E-05 | P04785, Q9R063, P10960, P07150, P07632, P63018, P35704, P30904, P19804, Q63716, P07943, R4GNK3 | 5.456 | 0.0017 |
| Hydrogen peroxide metabolic process | 6 | 1.39E-05 | A0A0G2JSV6, Q9R063, P07632, P62898, P35704, Q63716 | 19.164 | 0.0019 |
| Response to hydrogen peroxide | 9 | 6.74E-05 | A0A0G2JSV6, P10960, P07150, P07632, P63018, P30904, P07943, P05197, R4GNK3 | 6.570 | 0.0063 |
| Reactive oxygen species metabolic process | 10 | 1.15E-04 | A0A0G2JSV6, Q6MG60, Q9R063, P07632, P04906, P62898, P35704, Q63716, P82995, P62630 | 5.279 | 0.0095 |
| Cell redox homeostasis | 6 | 1.39E-04 | P04785, Q9R063, P35704, Q63716, P11598, R4GNK3 | 11.977 | 0.0108 |
| Extracellular matrix organization | 9 | 2.30E-04 | P29457, B2RZ77, Q9EQV9, P63018, P51886, P34058, P08699, P85845, P08460 | 5.502 | 0.0151 |
| Extracellular structure organization | 9 | 2.38E-04 | P29457, B2RZ77, Q9EQV9, P63018, P51886, P34058, P08699, P85845, P08460 | 5.475 | 0.0153 |
| Response to heat | 7 | 3.18E-04 | Q9EQV9, P07632, P63018, P30904, P14659, P82995, P31044 | 7.579 | 0.0186 |
| Positive regulation of viral process | 6 | 4.44E-04 | P04785, Q9EPH8, P45592, P10111, P63018, P11762 | 9.348 | 0.0238 |
| Cellular oxidant detoxification | 6 | 4.70E-04 | Q9R063, P07632, P04906, P35704, Q63716, R4GNK3 | 9.235 | 0.0248 |
| Pyridine nucleotide metabolic process | 7 | 5.12E-04 | P85973, Q9R063, P04636, P30904, Q01205, Q9EQS0, P26284 | 6.933 | 0.0254 |
| Nicotinamide nucleotide metabolic process | 7 | 5.12E-04 | P85973, Q9R063, P04636, P30904, Q01205, Q9EQS0, P26284 | 6.933 | 0.0254 |
| Cellular detoxification | 6 | 5.53E-04 | Q9R063, P07632, P04906, P35704, Q63716, R4GNK3 | 8.913 | 0.0259 |
| Pyridine-containing compound metabolic process | 7 | 6.52E-04 | P85973, Q9R063, P04636, P30904, Q01205, Q9EQS0, P26284 | 6.624 | 0.0285 |
| Detoxification | 6 | 6.81E-04 | Q9R063, P07632, P04906, P35704, Q63716, R4GNK3 | 8.517 | 0.0286 |
| Response to temperature stimulus | 8 | 7.59E-04 | Q9EQV9, P07632, P63018, P30904, P14659, P82995, P31044, D4A7V9 | 5.323 | 0.0304 |
| Response to axon injury | 6 | 8.70E-04 | P23593, P07632, P30904, P11762, P19527, R4GNK3 | 8.069 | 0.0335 |
| Oxidoreduction coenzyme metabolic process | 7 | 9.46E-04 | P85973, Q9R063, P04636, P30904, Q01205, Q9EQS0, P26284 | 6.168 | 0.0360 |
| Positive regulation of multi-organism process | 7 | 9.81E-04 | P04785, Q9EPH8, P45592, P10111, P63018, P30904, P11762 | 6.125 | 0.0365 |
CMT1A: Charcot-Marie-Tooth-1A; WT: wild type.