Table 3.
Mechanism of actions of trehalose studied in animal models of polyglutamine tract disease
| Study | Administration route | Other bioactive compounds | Mechanism of actions | ||
|---|---|---|---|---|---|
|
| |||||
| Autophagy flux | Protein refolding | Expression of reactive gliosis | |||
| Debnath et al., 2017 | Nanoparticles injection | ||||
| Im et al., 2013 | Oral | ||||
| Tanaka et al., 2004 | Oral | ||||
| Yang and Yu, 2009 | Oral | C17.2 stem cell transplantation | |||
| Santana et al., 2020 | Oral | – | |||
| Chen et al., 2015 | Oral | – | √ | ||
√ Presence of mechanism; – Examined but absent. Im et al. (2013) and Debnath et al. (2017) used trehalose derivative and trehalose-terminated nanoparticles, respectively.