Table 4.

Mechanism of actions of trehalose studied in animal models of amyotrophic lateral sclerosis

Study	Administration route	Mechanism of actions
		Autophagy flux	Expression of reactive gliosis	Protect against mitochondrial defect
Castillo et al., 2013	Injection	√	√
Li et al., 2015	Oral	√	√
Zhang et al., 2014	Oral	√		√

√ Presence of mechanism.