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. 2023 Jan 9;16:95–107. doi: 10.2147/JIR.S387127

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© 2023 Li et al.

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Double labeling of proBDNF with NeuN, GFAP or IBA-1 in the spinal cord after CFA intraplantar injection at day 1. (A–C) Double staining of NeuN (green, (A)) and proBDNF (red, (B)) in the ipsilateral spinal cord at CFA intraplantar injection at day 1. Arrows indicate co-localization of proBDNF and Neun. (D–F) Representative confocal microscopy images of proBDNF (red, (E)) with Iba1 (green, (D)). (G–I) Representative immunofluorescence images showing double labelling of proBDNF (red, (H)) with GFAP (green, (G)) in spinal cord. Arrows indicate co-localization of proBDNF and GFAP. Scale bars= 20 µM.

Abbreviations: proBDNF, brain-derived neurotrophic factor precursor; CFA, complete Freund’s adjuvant; GFAP, glial fibrillary acidic protein; IBA-1, ionized calcium binding adaptor molecule 1.