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. 2023 Jan 9;16:95–107. doi: 10.2147/JIR.S387127

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© 2023 Li et al.

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The cellular localization of p75^NTR in spinal cord after CFA intraplantar injection. (A–C) Double staining of p75^NTR (red, (A)) with NeuN (green, (B)) in the ipsilateral spinal cord dorsal horn at post-injection day 1. Note p75^NTR positive staining surrounds NeuN positive staining. Arrows indicate co-localization of p75^NTR and NeuN. (D–F) Double labeling of p75^NTR (red, (E)) with Iba1 (green, (D)) at day 1 post-injection. (G–I) Double staining of p75^NTR (red, (H)) with GFAP (green, (G)) in the ipsilateral spinal cord after CFA injection at day 1. Scale bars= 20 µM.

Abbreviations: proBDNF, brain-derived neurotrophic factor precursor; CFA, complete Freund’s adjuvant; p75^NTR, pan neurotrophin receptor 75.