Chemical structures of protectin D1 (PD1) and protectin D2 (PD2), biosynthesized from DHA, and the more recent members PD1n-3 DPA and PD2n-3 DPA, biosynthesized from n-3 DPA. PD1n-3 DPA and PD2n-3 DPA are congeners of PD1 and PD2, respectively, due to the lack of the Z-configured C4-C5 double bond in their n-3 DPA precursor.