. Author manuscript; available in PMC: 2023 Jun 1.

Published in final edited form as: Biochem Pharmacol. 2022 Oct 28;206:115330. doi: 10.1016/j.bcp.2022.115330

Table 1.

Examples of pro-resolving mechanisms of protectins. Please see text for key references and reviews [9], [13] and [23] for further details.

Mechanism	Cellular Function	Protectin
Efferocytosis	Upregulate	PD1, PD2, PCTR1-3, PD1_{n-3 DPA}
Phagocytosis	Upregulate	PD1, PD2, PCTR1-3, PD1_{n-3 DPA}
Bacterial clearance	Enhance	PD1, PCTR1-3
Neuroprotection	Enhance	PD1
Leukocyte infiltration	Limit	PD1, PD2, PCTR1-3, PD1_{n-3 DPA}
NF-_KB signaling	Downregulate	PD1
COX-2 activation	Inhibition	PD1
Pro-inflammatory chemokines and cytokines	Downregulate	PD1, PD1_{n-3 DPA}
Inflammasome formation	Downregulate	PD1
T-cell migration	Regulate	PD1