Table 3.

The in vivo effectiveness of quercetin loaded phytosome and quercetin on L. major promastigote incubated for different periods. Data are expressed as the mean ± SD (n = 5)

Drugs	Concentration	0 day	7 Days	14 Days	21 Days	28 Days	P value
Quercetin loaded phytosome	100 µg/ml	7.30 ± 1.28	8.82 ± 1.35	5.82 ± 1.54	3.57 ± 2.31	2.09 ± 0.93	0.001
	200 µg/ml	6.14 ± 2.41	5.73 ± 2.56	3.48 ± 2.88	3.15 ± 1.49	0.33 ± 1.22
	400 µg/ml	8.05 ± 2.43	5.37 ± 2.66	2.71 ± 1.21	0.94 ± 0.32	0.00 ± 0.00
Quercetin	100 µg/ml	7.43 ± 2.56	5.49 ± 1.56	4.38 ± 1.23	2.58 ± 0.45	1.53 ± 0.45
	200 µg/ml	7.96 ± 1.43	6.32 ± 2.11	3.58 ± 1.09	2.86 ± 1.31	2.05 ± 0.76
	400 µg/ml	8.49 ± 1.62	6.41 ± 1.87	3.29 ± 0.89	1.33 ± 0.96	0.83 ± 0.07
NC		7.55 ± 2.41	7.94 ± 1.11	8.37 ± 1.58	8.93 ± 2.03	8.94 ± 2.35
PC		8.77 ± 2.54	6.34 ± 1.94	3.41 ± 1.87	1.42 ± 1.02	0.00 ± 00

NC Negative control, PC Positive control (Glucantime)