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. 2023 Jan 10:1–14. Online ahead of print. doi: 10.1007/s11010-022-04657-0

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© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 3 — Treatment options for the monkeypox disease, and their underlying mechanisms of action. Brincidofovir and cidofovir stop the viral replication by inhibiting DNA polymerase enzyme. Tecovirimat on the other hand interferes with the viral envelope formation. Another antiviral drug NIOCH-14 is known to stop viral replication by serving as nucleoside