Fig. 3.

Functional divergence between the gut microbiota of SARS-CoV-2 Omicron-infected subjects and healthy controls. The bar charts showing KEGG on level 2 (a, c) and COG (b, d) pathways with significant differences. Functional pathways with a mean proportion larger than 0.5% in both groups are shown. Comparisons were performed between COVID-19 children and healthy children (HC), asymptomatic caregivers and healthy adults (HA) at KEGG pathway level 2 and COG pathway, respectively. Significance was determined by using Welch’s t test with P values adjusted by the Benjamini–Hochberg correction procedure for controlling the false discovery rate, ^*P ≤ 0.05, ^†P ≤ 0.01, ^‡P ≤ 0.001, ^§P ≤ 0.0001. COVID-19 coronavirus disease 2019, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, KEGG Kyoto Encyclopedia of Genes and Genomes, COG cluster of orthologous groups of proteins