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. 2023 Jan 13;6:42. doi: 10.1038/s42003-023-04431-y

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Fig. 5 — Illustration of aE11 recognition of the MAC. Under low concentration conditions little or no aE11 binding occurs. In addition, murine C9, which has a different aE11 binding interface to human C9, results in disruption of aE11 recognition. At high concentrations of monomeric C9, the partial neoepitope is weakly recognised by aE11. Stable formation of oligomeric C9 produces a long-lived, stable quaternary discontinuous epitope. Binding of aE11 to the oligomeric C9 component of the MAC is very strong.