Table 4.

Associations Between Person-Level Osmolarity and OSDI From Analysis of Combined Data From Baseline, Six Months, and 12 Months

Osmolarity	No. of Person Visits	OSDI Mean (SE)	P
No. of eyes with osmolarity >308 mOsm/L
As categorical			0.13
0	645	35.3 (0.8)
1	257	36.9 (1.3)
2	155	39.1 (1.8)
As continuous
Pearson r	1057	0.07	0.04
Abnormal osmolarity*
As categorical			0.79
No	481	36.1 (1.0)
Yes	627	36.4 (0.9)
Maximum tear osmolarity from two eyes of a patient (mOsms/L) (lower is better)
As categorical			0.13
≤308	684	35.5 (0.8)
>308 to ≤316	178	38.8 (1.6)
>316	246	36.9 (1.5)
As continuous
Pearson r	1108	0.02	0.62

^*Abnormal osmolarity defined at the person level as >308 mOsm/L in either eye or an intereye difference >8 mOsm/L.