Table 2.
Demographic characteristics of RNA-seq cohort
|
C9orf72 HRE carrier |
||||||
|---|---|---|---|---|---|---|
| Variable | Control (n = 65) | FTD (n = 20) | FTD-ALS (n = 7) | MCI (n = 10) | Presymp (n = 12) | p value |
| Age, years [mean (SD)] | 61.3 (6.7) | 60.6 (8.2) | 57.7 (11.2) | 57.5 (13.1) | 45.7 (9.2) | <1 × 10–5 |
| Sex, n male (%) | 27 (41.5) | 6 (30.0) | 5 (71.4) | 5 (50.0) | 3 (25.0) | NS |
| CDR-SB Score [mean (SD)] | 0 (0) | 7.6 (2.9) | 8.4 (3.5) | 1.3 (0.9) | 0 (0) | <1 × 10–5 |
CDR-SB, Clinical Dementia Rating scale Sum of Boxes; FTD, frontotemporal dementia; FTD-ALS, frontotemporal dementia with motor neuron disease; MCI, mild cognitive impairment; Presymp, Presymptomatic; SD, Standard deviation; T, Tesla; NS, not significant.