Figure 6.

Empirically observed changes in probability of connection are sufficient to account for cluster-specific differences in firing rates and correlations. A, Schematic of the changes made to the weight matrix compared with the baseline network in Figure 5A. B, Sample Up-states following manipulation of the synaptic coupling between Ex⁺ and Ex^– populations. C, Average firing rates of Ex^– and Ex⁺ units during Up-states were significantly different. D, There was a significant decrease in the mean pairwise Ex^–/Ex⁺ correlations compared with the Ex^–/Ex^– and Ex⁺/Ex⁺ correlations, as well as a weaker correlation in the Ex⁺/Ex⁺ compared with Ex^–/Ex^– pairs. Because the correlations are bounded between −1 and 1, we are using nonparametric sign-rank statistics; thus, all p values can be the same despite the differences in the group values.