Table 1.
Comparison of demographic, transfusion, medication, and hospitalization data for patients on chronic exchange transfusion therapy (CET) compared to those not on CET.
| Subjects on CET, N=11 | Subjects not on CET N=33 | P Value | |
|---|---|---|---|
| Age (Mean+/−SD) | 29.2±10.3 | 35.5±14.7 | 0.2 |
| Gender (% Female) | 45% | 61% | 0.4 |
| Genotype | SS/Sβ0 (82%) SC/Sβ+(18%) | SS/Sβ0 (58%) SC/Sβ+(42%) | 0.1 |
| Years on Chronic Transfusion Therapy Median (IQR) | 12.0 (3.0–15.5) | - | - |
| Opioids Dispensed (Daily OME) Median (IQR) | 3.9 (0.4–28.6) | 6.2 (0.8/102.9) | 0.5 |
| Ulcers (% with) | 9% | 9% | 1.0 |
| Avascular Necrosis (% with) | 9% | 15% | 0.3 |
| Hydroxyurea (%) | 0% | 49% | .004 |
| Hospital Admissions Median (IQR) | 1.0(0.0–1.50) | 2.0(0.0/5.0) | 0.2 |
| ED Visits Median (IQR) | 0.0 (0.0–0.50) | 1.0 (0.0/2.0) | 0.4 |
| Length of Stay (Days) (Mean ± SD) | 3.2±1.5 | 4.0±1.6 | 0.6 |
| Hemoglobin (g/dL) (Mean±SD) | 9.4±1.7 | 10.1±1.9 | 0.3 |
| MCV (fL) (Mean±SD) | 83.3±10.9 | 84.9±12.6 | 0.7 |
| Platelet (x10 9 /L) (Mean±SD) | 367.1±91.6 | 333.9±166.1 | 0.5 |
| WBC (x10 9 /L) (Mean±SD) | 11.6±3.8 | 9.6±3.4 | 0.2 |
| Neutrophil (x10 9 /L) (Mean±SD) | 7.8±2.7 | 5.4±2.1 | 0.006 |
| Lymphocyte (x109/L) (Mean±SD) | 2.4±1.0 | 2.9±1.4 | 0.3 |
| Monocyte (x10 9 /L) (Mean±SD) | 1.2±0.4 | 0.9±0.5 | 0.1 |
*
IQR=interquartile range.