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. 2023 Jan 3;19(1):e1010756. doi: 10.1371/journal.pcbi.1010756

Table 1. Sixteen HIV amino acid (AA) positions where Shannon entropy was significantly associated with viral load (VL).

Gene AA position Effect size (95% CI) p-value Mean Shannon entropy CTL epitope coordinates (HLA alleles) a
Pol 34 0.229 (0.129–0.330) 7.53×10−6 0.10
Pol 75 0.262 (0.156–0.369) 1.32×10−6 0.07
Pol 97 0.221 (0.143–0.298) 3.15×10−8 0.19 90–98 (B*44)
Pol 195 0.161 (0.089–0.233) 1.09×10−5 0.28 188–198 (C*01:02)
Pol 329 0.263 (0.146–0.380) 1.02×10−5 0.07 328–336 (A*30:02, C*12:02)
Pol 441 0.338 (0.213–0.463) 1.33×10−7 0.09
Env 32 0.168 (0.095–0.240) 5.96×10−6 0.22 31–39 (B*18:01,B*44); 31–40 (B*44:02)
Env 87 0.136 (0.076–0.196) 8.71×10−6 0.34
Env 102 0.340 (0.193–0.487) 6.03×10−6 0.06
Env 240 0.162 (0.090–0.234) 1.03×10−5 0.23
Env 336 0.168 (0.098–0.237) 2.41×10−6 0.34
Env 453 0.400 (0.246–0.555) 4.17×10−7 0.07
Env 674 0.246 (0.147–0.345) 1.36×10−6 0.18
Env 775 0.353 (0.192–0.513) 1.70×10−5 0.07 770–780 (A*03:01, A*30:01)
Env 812 0.274 (0.149–0.399) 1.78×10−5 0.10 805–814 (B*40:01)
Nef 15 0.210 (0.119–0.301) 6.50×10−6 0.22 13–20 (B*08:01)