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. 2023 Jan 13;87(12-13):1662–1678. doi: 10.1134/S0006297922120215

Fig. 5.

Fig. 5.

Replication and transcription of subgenomic RNAs take place within the double-membrane vesicle (DMV). The polymerase complex consists of nonstructural proteins nsp7, nsp8, nsp9, nsp10, nsp12, nsp13, nsp14, and nsp16 (indicated by numbers). RNA produced inside the DMV exits through the membrane pores. Subgenomic RNAs are translated into non-structural and accessory proteins; N protein meets with genomic RNA and forms a nucleocapsid.