Table 2.
The outcomes and complications from largest pleurectomy decortication series.
| Author (year) | Study design | No. ePD treated patients | Treatment regimen | 30-day mortality* | Major complications (>grade 3)* | Overall survival (Median, mo)* |
|---|---|---|---|---|---|---|
| Lapidot22 (2020) | Single-center, observational | 355 | IOHC1 (80%) Induction CHT2 (24%) Adjuvant CHT (67%) |
3.0% | 47% | 20.7 (ITT3) 23.2 (MCR4) |
| Klotz33 (2019) | Single-center, observational | 71 | IOHC (100%) Induction CHT (11%) |
1.4% | NS | 16.1 |
| Verma20 (2017) | National cancer registry | 1036 | NS5 | 5% | NA | 16 |
| Friedberg23 (2017) | Single-center, observational | 73 | IOPDT6 (100%) Induction CHT (23%) Adjuvant CHT (84%) |
3% | NS | 36 |
| Shaikh24 (2017) | Single-center, observational | 209 | Adjuvant RT7 (100%), CHT (41%) | NS | NS | 20.2 (IMPRINT) 12.3 (CONV) |
| Lang-Lazdunski25 (2015) | Single-center, observational | 102 | IOHPI8 (100%) Induction CHT (14%) Adjuvant RT (100%), CHT (81%) |
0 | NS | 32 |
| Williams26 (2015) | Single-center, observational | 117 | Induction CHT (18%) Adjuvant CHT (62%) |
3.4% | 9% | 14.4 |
| Sharkey27 (2015) | Single-center, observational | 229 | Induction CHT (17%) Adjuvant CHT (32%) |
3.5% | NS | 12.3 |
| Nakas28 (2014) | Single-center, observational | 140 | Induction CHT (NS) Adjuvant CHT (NS) |
NS | NS | 16.2 |
| Bovolato29 (2014) | Multicenter, observational | 202 | Adjuvant CHT (79%), RT (6%) | 2.6% | NS | 20.5 |
| Burt21 (2014) | Multicenter database | 130 | NS | 3.1% | 3.8% | NS |
| Flores13 (2008) | Multi-center, observational | 278 | Adjuvant CHT (NS) Adjuvant RT (NS) |
4% | 8% | 16 |
| Lucchi31 (2007) | Phase II single-arm | 49 | Induction IIL29 (100%) Adjuvant IE10 (100%), IIL2 (100%) RT (100%), CHT (100%) |
0 | NS | 26 |
| Richards74 (2006) | Phase I-II single-arm | 44 | IOHC (100%) | 11% | 25% | 13 |
| Gupta30 (2005) | Single-center, observational | 123 | IOBT11 (44%) Induction CHT (5%) Adjuvant CHT (7%), RT (100%) |
3.3% | 37% | 13.5 |
1.
IOHC, intraoperative heated chemotherapy;
2.
CHT, chemotherapy;
3.
ITT, intention-to-treat;
4.
MCR, macroscopic complete resection;
5.
NS, not specified;
6.
IOPDT, intraoperative photodynamic therapy;
7.
RT, radiotherapy;
8.
IOHPI, intraoperative heated povidone-iodine;
9.
IIL2, intrapleural interleukin-2;
10.
IE, intrapleural epidoxorubicin;
11.
IOBT, intraoperative brachytherapy;
*
Refers to the outcomes of ePD group.