Table 4:

Distribution of overall survival by treatment arm and metformin use

	ADT+D+metformin (n=39)	ADT+D/No metformin (n=357)	ADT+metformin (n=29)	ADT/No metformin (n=363)
Overall survival (months)
Median	52.0	58.0	43.5	48.1
95% CI	27.7, 76.9	52.1, 63.9	23.5, NA	40.7, 53.3
Number of deaths	22	166	15	196
Number of PC deaths	15	132	12	164
p-value (stratified* logrank)	0.31 (compare metformin y/n in ADT+D arm)		0.76 (compare metformin y/n in ADT alone arm)

^*stratified on stratification factors at randomization