Figure 7.

Integration site profile of intact proviruses from study persons with virological rebound after ART interruption

(A) Longitudinal analysis of HIV-1 plasma viral load in three study persons who developed rapid viral rebound following ART interruption. PBMC sampling time points are indicated by arrows.

(B) Maximum likelihood phylogenetic tree for intact proviruses isolated from PBMC samples prior to ART interruption in three rebounders shown in (A). Chromosomal integration sites are indicated when available.

(C) Proportions of intact and defective proviruses with indicated integration sites in PTC.

Data from intact proviruses identified in rebounders are shown for comparison. Data from the time point immediately prior to treatment interruption are shown; clonal sequences are counted individually. Significance was calculated using a chi-square test, adjusted for multiple comparison testing. n reflects the number of integration sites.