Fig. 2.

Imatinib is present in blood plasma during ischaemia and reperfusion. Rats were subjected to 45 min left anterior descending coronary artery ligation and 180 min reperfusion, and assessed for the extent of reperfusion injury. A Intravenous administration of one bolus of 30 mg/kg imatinib or placebo 15 min prior to ischaemia. B Blood plasma concentration of imatinib and C its main metabolite N-desmethyl imatinib were determined at 15 (end of baseline), 60 (end of ischaemia) and 240 (end of reperfusion) minutes after imatinib administration. Every ● represents one rat with n = 7 (15 min), n = 6 (60 min) and n = 5 (240 min). The plus sign represents the mean. Data is presented as median with IQR, whiskers min to max