Extended Data Fig. 3. Sensitivity analyses on accuracy of observed variant proportions for different relative transmissibility factor.

Omicron-like virus properties assumed for variant and initial proportion of population with some degree of protection against the variant virus assumed at 10%. All specimens collected from the population from all healthcare facilities were sent to one facility to be sampled for sequencing (population-wide genomic surveillance strategy). Different transmissibility factor of Omicron relative to Delta (f_mutant) were assumed. (A) Maximum absolute difference between observed and circulating variant proportions. (B) Proportion of timepoints when sequencing was performed that the absolute difference between observed and circulating variant proportions is greater than 20%. All results were computed from 1,000 random independent simulations for each surveillance strategy.