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. 2022 Dec 21;55(1):66–77. doi: 10.1038/s41588-022-01243-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (a) Marker dot plot for myelinating, non-myelinating Schwann cells and for epi- and endoneurial NAF-s. (b, c) g:Profiler gene set enrichment results using g:GOSt method and g:SCS threshold and multiple testig correction with flat list as input for myelinating Schwann cell markers with detailed results for myelination and transcription factor EVX1 (b) and for non-myelinating Schwann cell markers (c). (d) Expression of neuropathy associated genes in Schwann and NAF cell types. Previously unknown cell type specific expression shown in colour: light green for novel expression pattern, light blue for distinguishing expression for nmSchwann cells. (e) Expression in Transcript per million (TPM) of NAF markers in GTEx bulk RNA-seq data. (f) Visium ST H&E staining of human bronchi, with zoom in on nerve bundle and cell2location cell type mapping density scores for Schwann and NAF cell types. (g-i) HPA antibody staining of (g) non-myelinating Schwann cell markers (CADM, GRIK2, NCAM1, ITGB4 and L1CAM) (h) endoneurial NAF marker (USP54) and (i) perineurial NAF markers (SLC22A3 and SORBS1) within the nerve bundles in human bronchus. Arrows indicate nerve bundles. (j) RNAscope staining for myelinating (MLIP) and non-myelinating (SCN7A, SOX10) Schwann cell and perineurial (SLC2A1) NAF specific genes in bronchial nerves.