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. 2022 Dec 21;55(1):66–77. doi: 10.1038/s41588-022-01243-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a) Markers dot plot for vascular endothelia. (b) cell2location density scores of pulmonary and vascular endothelium for parenchyma and bronchi Visium ST sections. (c) Bronchi section with H&E and cell2location analysis density score for airway smooth muscle population on a Visium ST slide. (d) NPR2 staining in oesophagus and bronchus from the HPA. Black arrows indicate the airway and oesophagus surrounding non-vascular smooth muscle. (e) ASM marker expression in all GTEx tissues. Tissues are ordered by unsupervised clustering based on expression similarity. The dotted line highlights tissues which are surrounded by a thick smooth muscle layer. The orange rectangle shows muscular tissues from oesophagus, and the blue rectangle shows the non-muscular mucous layer of oesophagus tissue. (f) IR-Ven-peri markers localise at the venous vessels in the airway. smFISH staining for IR-Ven-peri (CCL21, CCL19), venous endothelia (ACKR1) and smooth muscle (ACTA2) markers. (g) Leukocyte rolling and homing genes, and chemokines expressed in Endothelia and SM/Perivascular cells together with their interaction partners expression in immune cell groups. Interaction partners are indicated with blue shades.