FIG. 2.

Passive protective efficacy of rabbit antibodies to E. faecalis 12030 CP antigen. (a) CFU of E. faecalis strain 12030/gram of liver, spleen, or kidney of mice receiving either IRS, NRS, or saline and challenged with 10⁷ CFU of E. faecalis 12030 per mouse. Sera were adsorbed with whole cells of heterologous E. faecalis 12107 before administration to the mice. Each point represents the bacterial counts from a single mouse. Bars indicate the median CFU/gram of tissue for the group. P was ≤0.004 for reductions in CFU/gram of tissue in the liver, spleen, and kidney for IRS-treated mice versus the other two treatments as determined by the Kruskal-Wallis test and Dunn procedure for pairwise comparisons with NRS or saline. (b) CFU of E. faecalis per gram of liver, spleen, or kidney of mice after prophylactic administration of IRS or NRS adsorbed with E. faecalis 12030 and challenge with 6 × 10⁶ CFU of E. faecalis 12030 per mouse. Each point represents the bacterial counts from a single mouse. Bars indicate the median CFU/gram of tissue for the group. P was >0.7 for all comparisons as determined by the Mann-Whitney U test.