Chimeric antigen receptor	T cell receptor	Tumor infiltrating lymphocyte
Advantages	Advantages	Advantages
Treatment not limited by HLA type Antigen presentation machinery not required Shorter manufacturing time than TIL Does not require surgery	Targeting not restricted by antigen localization Shorter manufacturing time than TIL Does not require surgery	Potential for targeting of multiple antigens Antigen targeting does not need to be defined Targeting not restricted by antigen localization
Disadvantages	Disadvantages	Disadvantages
Targeting limited to the extracellular domain of a membrane-anchored protein (some exceptions) Defined target antigen required Evasion by loss of target antigen surface expression Targets a single antigen (some exceptions)	Treatment limited by HLA type Evasion by loss of antigen presentation machinery Defined target antigen required Targets a single antigen	Antigen targeting is highly variable between cell products Requires surgery Longer manufacturing time than engineered cells