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Major Mutation Mechanisms of Ibrutinib Resistance
| Primary Sensitivity | Primary Resistance/Reduced Sensitivity | Predisposition for Later Progression | Secondary Resistance | |
|---|---|---|---|---|
| CLL | UM-IGHV * | TP53 del/mut, complex cytogenetics Del 18p |
BTK PLCG2 Del 8p/TRAIL-R |
|
| MCL | CARD11 CCND1 TRAF2, TRAF3 & BIRC3 and MAP3K14 |
BTK CCND1 CDKN2A/MTAP |
||
| DLBCL | MCD or N1 molecular subtypes | CARD11 TNFAIP3 KLHL14 PIM1 |
