Table 2.
Univariate proportional hazards models of metastasis‐free survival in a case–cohort of intermediate‐ and high‐risk men
| Variables | HR (95% CI) | p Value |
|---|---|---|
| Year of surgery | 1.50 1.12, 2.02) | 0.007 |
| Age | 0.99 (0.93, 1.05) | 0.671 |
| PSA (per 1 ng/ml) | 1.03 (0.996, 1.07) | 0.079 |
| Gleason score | <0.0001 | |
| 7–8 | 1.0 | |
| 9–10 | 13.48 (5.40, 33.65) | |
| Pathologic stage | <0.0001 | |
| Organ‐confined | 1.0 | |
| Extraprostatic extension | 3.95 (1.27, 12.32) | |
| Seminal vesicle involvement | 17.05 (3.83, 75.83) | |
| Lymph node involvement | 61.46 (11.58, 326.33) | |
| CAPRA‐S (per 1 unit) | 2.32 (1.79, 3.01) | <0.0001 |
| Total PACCs (per 1 PACC) | 1.38 (1.09, 1.73) | 0.006 |
| Total PACCs (≥1 vs. 0)a | 2.70 (1.24, 5.86) | 0.012 |
| Cores with PACCs (per 1 core) | 1.40 (1.004, 1.94) | 0.047 |
| Cores with PACCs (≥1 vs. 0)a | 2.70 (1.24, 5.86) | 0.012 |
Abbreviations: CAPRA‐S, Cancer of the Prostate Risk Assessment Postsurgical; CI, confidence interval; HR, hazard ratio; PACCs, polyaneuploid cancer cells.
a
Binary classification of total PACCs and cores with PACCs gives the same distribution, so results from the proportional hazards model are also the same.