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. 2023 Jan 13;13:683. doi: 10.1038/s41598-023-27985-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phosphorylating respiration is not affected by Nkx6.1 ablation—panels show for wt (gray), INS-1E^scrl/scrl (black), line a (green) and b (dark green) of INS-1E^{Nkx6.1–/–} cells at 3 mM and 20 mM glucose: (a) Rates of phosphorylating (endogenous) respiration (V₃); (b) parameters Rr = V₃/V₄, i.e. ratios of V₃ to non-phosphorylating respiration rates (V₄), which reflect OXPHOS intensity; (c) parameters Ar = (V₃ – V₄) / FCCP, where the FCCP is the uncoupled rate in the presence of uncoupler FCCP (titrated to optimum concentration yielding a maximum rate); (d) Ratios of FCCP/V₄. Number of cell passages N was 3–6 on which n of 5–13 respiration assays were performed. ANOVA: ***p < 0.001; **p < 0.05.